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KMID : 0383819840310030116
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Tuberculosis and Respiratory Diseases
1984 Volume.31 No. 3 p.116 ~ p.120
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The Effect of Cyclidrol(MucofluxR) as a Mucolytic Agent in Respiratory Diseases
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손희영/Hee Young Sohn
장준/장양수/장상호/김성규/김기호/Joon Chang/Yang Soo Chang/Song Ho Chang/Sung Kyu Kim/Ki Ho Kim
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Abstract
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Forty patients with various respiratory diseases underwent a 7-day treatment using
either cyclidrol 400 ㎎ a day or placebo in the same dose and shape.
Tests aimed to evaluate the time course of respiratory symptoms. Parameters such as
sputum amount, thickness, purulence, difficulty in expectoration and cough were scored
in 4 scale and recorded before and after 7-days' treatment. Symptoms revealing
bronchial cleaning action such as expectoration and easiness of cough were more
significantly improved in experimental group than in control group(p<0.001 vs p<0.05).
And sputum thickness, the indirect index of sputum viscosity was much lowered also in
experimental group(p<0.05). Furthermore overall efficacy was estimated according to the
total score of 5 items in an individual patients. Responders(excellent and good result)
was 70% in experimental group, whereas 25% in control group(exact probability
p=0.001). Therefore cyclidrol, according to the previous reports, to be a good oral
mucolytic agent to cleanse diseased airway.
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KEYWORD
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